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2 edition of Preparation of new benzothiazoles. found in the catalog.

Preparation of new benzothiazoles.

Arthur Stull

Preparation of new benzothiazoles.

Acid anhydride and acid chloride derivatives of di-o-aminophenyl disulfide ...

by Arthur Stull

  • 271 Want to read
  • 11 Currently reading

Published in New York, N.Y .
Written in English

    Subjects:
  • Benzothiazoles.,
  • Aminophenyl disulphide.

  • Edition Notes

    Statementby Arthur Stull ...
    Classifications
    LC ClassificationsQD403 .S8 1925
    The Physical Object
    Pagination28 p., 1 l.
    Number of Pages28
    ID Numbers
    Open LibraryOL6680627M
    LC Control Number25017187
    OCLC/WorldCa29775295

    Benzothiazole: Different Methods of Synthesis and Diverse Biological Activities P S Yadav new products that possess biological activities, such as antimicrobial, anticancer, antifungal, anthelmintic, anti-diabetic, The present review focus on the different methods of synthesis of substituted benzothiazoles with potential activities that File Size: KB. Efficient synthesis of various benzimidazoles and benzothiazoles under mild conditions catalyzed by Cu(II) anchored onto UiO–NH{sub 2} metal organic framework is reported. In this manner, first, the aminated UiO was modified with thiophenecarbaldehyde and then the prepared Schiff base was reacted with CuCl{sub 2}.


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Preparation of new benzothiazoles. by Arthur Stull Download PDF EPUB FB2

Benzothiazole is an aromatic heterocyclic compound with the chemical formula of C7H5NS. Benzothiazole: Preparation, Structure and Uses opens with a review on the synthesis of benzothiazoles for their anticancer, antimicrobial, antidiabetic, anticonvulsant, anti-inflammatory, anthelmintic, analgesic, antiviral and antitubercular activities.

Following this, considering the versatile nature of. Preparation of new benzothiazoles.: Acid anhydride and acid chloride derivatives of di-o-aminophenyl disulfide / by Arthur Stull Author/Creator.

Structure and preparation. Benzothiazoles consist of a 5-membered 1,3-thiazole ring fused to a benzene nine atoms of the bicycle and the attached substituents are coplanar. Benzothiazoles are prepared by treatment of 2-mercaptoaniline with acid chlorides.

C 6 H 4 (NH 2)SH + RC(O)Cl → C 6 H 4 (NH)SCR + HCl + H 2 O Uses. This heterocyclic scaffold is readily substituted at the unique Boiling point: to °C ( to °F; to K). Benzothiazoles are most commonly prepared by the ring closure of methodology has been well reviewed in both CHEC() and CHEC-II().Typically an o-aminothiophenol is reacted with a suitable electrophile such as an aldehyde, a carboxylic acid, or an ester in a suitable solvent at reflux to provide the desired.

Different synthetic paths have been developed for the preparation of benzothiazole derivatives ().Among them, the condensation reaction of 2-aminobenzenethiol with a carbonyl or cyano group-containing substance is the most commonly used method (Scheme 1, Method 1) [26,27].Riadi and co-workers [] found that benzothiazoles could be synthesized from the condensation of 2-aminobenzenethiol and.

Benzothiazole nucleus containing molecules are also reported as anti‐allergic,6 anti‐diabetic,7 antitumor,8 anti‐inflammatory, anti-helmintic, and anti‐HIV agents. 2-aryl substituted benzothiazoles show antitumor activity while condensed pyrimido-benzothiazoles and benzothiazolo-quinazolines showed anti‐viral activity Patel NB and Shaikh FM: Synthesis of new pyridine based 4-thiazolidinones incorporated benzothiazoles and evaluation of their antimicrobial activity.

Journal of Sciences21(2): Saeed S, Rasshid N, Jones P, Ali M and Hussain R: Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole. The invention relates to a process for the preparation of benzothiazole derivatives of the formula ##STR4## in which R represents H, NH 2 or R 1, R 1 denoting alkyl or aryl, and it being possible for the ring A to have other substituents, which is characterised in that appropriate aminobenzenes or nitrobenzenes which have a suitable leaving group in the ortho position are reacted with an.

Uneyama’s preparation of fl uorinated imidoyl chlorides to the efficient synthesis of various 2-trifluoromethyl and 2- difluoromethyl subs tituted benzo-1,3-diazole derivatives via a. New synthesis and biological evaluation of benzothiazole derivates as antifungal agents. Herrera Cano N(1), Ballari MS(1), López AG(2), Santiago AN(1).

Author information: (1)†INFIQC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, by: Benzothiazoles have promising biological profile and are easy to access which makes this pharmacophore an interesting moiety for designing new benzothiazoles.

Benzothiazole moiety has wide applications in dyes such as thioflavin [14]. Some of the marketed drugs comprising benzothiazole are shown in Fig. 1 [15–17]. Conclusion: Design of novel inhibitors targeting enzymes that regulate sphingolipid biosynthesis and turnover could change the landscape for the development of new anticancer drugs.

Keywords: Thieny- benzothienyl- imidazolinyl- substituted benzothiazoles, acid ceramidase inhibitor, sphingosine kinase 1. An update on the synthesis of benzoxazoles. New methods for the preparation of the anhydro compounds. in the presence of 2-aminothiophenol 1 gave 2-substituted benzothiazoles 3 in good.

Extraction and analysis of various benzothiazoles from industrial wastewater Oliver Fiehn, Thorsten Reemtsma *, Martin Jekel Department of Water Quality Control, Technical University of Berlin, Sekr. KF 4, Strasse des JuniD FRG Received 26th October ; revised manuscript received 15th March File Size: KB.

US-A-4 describes a process for the preparation of benzothiazolesulphenamides, in which an oxidising agent such as sodium hypochlorite is added slowly to a mixture prepared from 2-mercaptobenzothiazole, amine, and water or water and solvent.

The process employs from to 4 moles of amine per mole of 2-mercaptobenzothiazole. General Papers ARKIVOC (xv) Synthesis and in vitro antiproliferative activity of new benzothiazole derivatives Yaseen A. Al-Soud,1 Haitham H. Al-Sa’doni,1 Bahjat Saeed,2 Ihsan H.

Jaber,1 Mohammad O. Beni-Khalid,1 Najim A. Al-Masoudi,3,* Tahsin Abdul-Kadir,2 Paolo La Colla,4 Bernardetta Busonera,4 Tiziana Sanna,4 and Roberta Loddo4 1 Department of Chemistry, College of Science.

Downer et al., have introduced a new and applicable protocol for the intramolecular cyclization of thiobenzamides to benzothiazoles through the aryl radical cations as reactive intermediates (Sch Method 3) The protocol uses phenyliodine (III)bis(trifluoroacetate) (PIFA) in trifluoroethanol or cerium ammonium nitrate (CAN) in aqueous.

Dicarba-closo-dodecaboranes, commonly known as carboranes, possess unique physico-chemical properties and can be used as hydrophobic moieties during the design of new drugs or radiotracers. In this work, we report the synthesis of two analogues of 2-(4-aminophenyl)benzothiazole (a compound that was found to elicit pronounced inhibitory effects against certain breast cancer cell lines in vitro Cited by: 7.

Preparation The synthesis is described in Schemes 1 and 2. Starting, 2-[2-(4-methylphenyl)ethenyl]-1,3-benzothiazole 3 was synthesized according to the procedure reported in the literature The compound 3 was reacted with N-bromosuccinimide in dry benzene and subsequently it was.

A Novel Practical Synthesis of Benzothiazoles via Pd-Catalyzed Thiol Cross-Coupling Takahiro Itoh and Toshiaki Mase Organic Letters 9 (18), Cited by: Synthesis of new 7-alkyl /aryl amino furo 2 substituated phenyl carboxamido (1,3) benzothiazoles as anthelmintic agents.

Design, synthesis, and evaluation of antitubercular activity of a novel benzothiazole-containing an azetidinone ring. Benzothiazole can serve as unique and versatile scaffolds, especially in synthetic and pharmaceutical chemistry because of their potent and significant pharmacological activities.

This important class of derivatives possess numerous pharmacological activities. Benzothiazole is a class of heterocyclic compounds having 2 hetero atoms namely, sulphur and nitrogen. The analogues of benzothiazoles and its derivatives have a significant role in research area especially in synthetic, medicinal and pharmaceutical chemistry because of Cited by: 8.

New conjugated benzothiazole-N-oxides: synthesis and biological activity. Gajdos P(1), Magdolen P, Zahradník P, Foltínová P. Author information: (1)Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Mlynskádolina CH-2, 15 Bratislava, by: In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties.

Benzothiazole is among the usually occurring heterocyclic nuclei in many marine as well as natural plant products. Benzothiazole is a privileged bicyclic ring system with multiple applications. It is known to exhibit a wide range of Cited by: Benzothiazole definition is - a liquid compound C7H5NS made by cyclization from ortho-amino-thiophenol and formaldehyde well known as a parent compound of mercaptobenzothiazole and many dyes.

Convenient route synthesis of some new benzothiazole derivatives and their pharmacological screening as antimicrobial agents Published: Aug 34/46 1H-pyrano]2,3-d[pyrimidinyl)oxopropanenitrile (6) in 87% yield (Figure 3).

Structure 6 was conirmed by. The reactions between lithium-benzothiazoles and (S)-N-tert-butanesulfinylketimines have been found to be of general synthetic importance for asymmetric preparation of previously unknown type of amino-benzothiazol derivatives of high pharmaceutical most cases, the reactions proceed with excellent diastereoselectivities and good isolated yields of the target compounds rendering the.

Vinylic Tellurides: From Preparation to Their Applicability in Organic Synthesis Gilson Zeni *, Diogo S. Lüdtke, Rodrigo B. Panatieri, and Antonio L. Braga Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS, BrazilCited by: Looking into their pharmacological importance, here in we report the synthesis of some new benzothiazole derivatives () using 2-(4-aminophenyl)benzothiazolol (1d) as the parent compound and their biological activity.

Materials And Methods Preparation of [(4-hydroxyphenyl)azaneyl)(4-nitrophen)]methanone (1a)[18]File Size: KB. Benzothiazoles show a chemotherapeutic activity and a considerable amount of work has been done on the synthesis of new potent antibacterial and antifungal benzothiazoles.

2‐(substituted phenylsulfonamido)‐6‐substituted Benzothiazoles 24 (fig.3) wereFile Size: KB. of newer agents. Reports of drugs for new indications as well as the occurrence of brand-new structural types as drugs made it particularly important to update the existing volumes.

The five-year cycle for preparation of new volumes represents a compromise between timeliness and comprehensiveness. A shorter period would date earlier entries. T1 - Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts.

AU - He, Guochun. AU - Zhao, Bin. AU - Denison, Michael S. PY - /8. Y1 - /8Cited by: Structure and preparation. Benzothiazoles consist of a 5-membered 1,3-thiazole ring fused to a benzene nine atoms of the bicycle and the attached substituents are coplanar.

Benzothiazole are prepared by treatment of 2-aminobenzenethiol with acid chlorides: [1]. C 6 H 4 (NH 2)SH + RC(O)Cl → C 6 H 4 (NH)SCR + HCl + H 2 O UsesCAS number: Green Condensation of o-Aminothiophenol to o-Phenyl-benzothiazole David Fairchild, Alex Irion, Dominic Russo, Luke Sanders Abstract Herein we describe a simple, efficient, and environmentally friendly synthesis of o-arylbenzothiazoles, such as o-phenyl-benzothiazole, under standard ambient temperature and pressure via reaction of o-aminothiophenols with aromatic.

Various benzothiazoles such as 2-substituted benzothiazole received much attention due to unique structure and its uses as radioactive amyloidal imagining age and anticancer agents In the s, a number of 2-aminobenzothiazoles were intensively studied, as the 2- amino benzothiazole scaffold is one of privileged structure in.

Mass spectral data. The anti-inflammatory activities of new compounds were determined by -Carrageenan-induced mice paw edema method using diclofenac sodium as a standard.

Among the compounds tested three compounds Bt2 (5-chloro-1,3-benzothiazoleamine), Bt (6-methoxy-1,3-benzothiazoleamine) and Bt7 (6-methoxy-1,3-benzothiazole-File Size: KB. of new potent antineoplastic agents and on the discov-ery of novel biological targets.

Novel benzothiazole--thiol derivatives were synthesized by Wang et al. [ ], and their antiproliferative activities on HepG and MCF- cells were investigated.

Most compounds had inhibitory e ects on cell growth, and some of them were more e ective than cisplatin. Media in category "Benzothiazoles" The following 45 files are in this category, out of 45 ss of: heteroarene.

Safety evaluation of certain food additives and contaminants prepared by the fifty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Phenothiazines and 1, 4-benzothiazines: Chemical and biomedical aspects (Bioactive molecules) [Gupta, R.R.] on *FREE* shipping on qualifying offers.

Phenothiazines and 1, 4-benzothiazines: Chemical and biomedical aspects (Bioactive molecules)Format: Hardcover.A solution of g.

(1 mole) of p-toluidine (Note 1) in ml. of chlorobenzene is prepared in a 3-l. three-necked, round-bottom flask fitted with a stirrer, reflux condenser, thermometer, and dropping a period of 5 minutes, 54 g.

( ml., mole) of concentrated sulfuric acid is added dropwise. To the finely divided suspension of p-toluidine sulfate is added 90 g. Textiles play an important role in our daily life, and textile production is one of the oldest industries.

In the manufacturing chain from natural and/or synthetic fibers to the final clothing products, the use of many different chemicals is ubiquitous. A lot of research has focused on chemicals in textile wastewater, but the knowledge of the actual content of harmful chemicals in clothes sold Cited by: